Nod-Like Receptors in Host Defence and Disease at the Epidermal Barrier

The nucleotide-binding domain and leucine-rich-repeat-containing family (NLRs) (sometimes called the NOD-like receptors, though contains few bona fide receptors) are a superfamily of multidomain-containing proteins that detect cellular stress microbial infection. They constitute critical arm innate immune response, their functions not restricted to pathogen recognition members engage in controlling inflammasome activation, antigen-presentation, transcriptional regulation, cell death also embryogenesis. NLRs found from basal metazoans plants, zebrafish, mice humans individual can vary species species. display highly wide-ranging tissue expression. Here, we discuss importance response at epidermal barrier summarise known role pathogenesis skin disease.